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  • 產(chǎn)品名稱：兔抗MAPK8/MAPK9/MAPK10 (phosphoThr183/Tyr185)多克隆抗體

  • 產(chǎn)品型號(hào)：100ul
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價(jià)格：1800
  • 產(chǎn)品庫(kù)存：60
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中文名稱：  兔抗MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185)多克隆抗體   

英文名稱： Anti-MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185) rabbit polyclonal antibody

別    名： Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; JNK-46

相關(guān)類(lèi)別： 一抗

儲(chǔ)    存： 冷凍（-20℃） 避光

宿    主： Rabbit

抗    原： MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185)  

反應(yīng)種屬： Human, Mouse, Rat

標(biāo) 記 物： Unconjugate

克隆類(lèi)型： rabbit polyclonal

技術(shù)規(guī)格

Background:

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Applications:

WB, IF

Name of antibody:

MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185)

Immunogen:

Synthetic peptide of human MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185)

Full name:

MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185)

Synonyms：

Stress-activated protein kinase JNK1 ; c-Jun N-terminal kinase 1; JNK-46

SwissProt:

P45983/P45984/P53779

WB Predicted band size:

46 kDa; 54 kDa

WB Positive control:

C6 cells treated with anisomycin

WB Recommended dilution:

500-1000

IF Positive control:

Hela cells

IF Recommended dilution

100-200


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