產(chǎn)品中心
產(chǎn)品詳情

  • 產(chǎn)品名稱：兔抗MAPKAPK2(Ab272) 多克隆抗體

  • 產(chǎn)品型號：100ul
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：1560
  • 產(chǎn)品庫存：60
  • 產(chǎn)品文檔：
你添加了1件商品 查看購物車
簡單介紹：
兔抗MAPKAPK2(Ab-272) 多克隆抗體“惠"到底，特價風(fēng)暴覆蓋國內(nèi)。產(chǎn)品種類眾多，全程實驗操作指導(dǎo)，高質(zhì)量，低價格，質(zhì)量保證，我們擁有先進的研發(fā)技術(shù)和雄厚的科學(xué)實力，我們以誠信為本，顧客至上，合理的價格、上等的產(chǎn)品服務(wù)廣大新老客戶，提供免費代測服務(wù)，熱誠歡迎新老客戶前來咨詢報價，索取說明書，咨詢購買事宜。
詳情介紹：


中文名稱：  兔抗MAPKAPK2(Ab-272) 多克隆抗體 

英文名稱： Anti-MAPKAPK2(Ab-272) rabbit polyclonal antibody

別      名： MK2; MK-2; MAPKAP-K2

相關(guān)類別： 一抗

儲      存： 冷凍（-20℃） 避光

抗      原： MAPKAPK2(Ab-272)

宿      主： Rabbit

反應(yīng)種屬： Human

標 記 物： Unconjugate

克隆類型： rabbit polyclonal

技術(shù)規(guī)格

Background:

Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.

Applications:

WB, IHC

Name of antibody:

MAPKAPK2(Ab-272)

Immunogen:

Synthesized non-phosphopeptide derived from human MAPKAPK2 around the phosphorylation site of serine 272 (A-I-S(p)-P-G).

Full name:

mitogen-activated protein kinase-activated protein kinase 2

Synonyms：

MK2; MK-2; MAPKAP-K2

SwissProt:

P49137

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

46 kDa

WB Positive control:

COS cells lysate

WB Recommended dilution:

500-3000





姓名：
電話：
您的需求：