中文名稱: MAP3K7 抗原(重組蛋白)
英文名稱: MAP3K7 Antigen (Recombinant Protein)
別 名: mitogen-activated protein kinase kinase kinase 7; CSCF; FMD2; TAK1; MEKK7; TGF1a
儲 存: 冷凍(-20℃)
相關(guān)類別: 抗原
概 述
Fusion protein corresponding to a region derived from 401-579 amino acids of human MAP3K7
技術(shù)規(guī)格
Full name:
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mitogen-activated protein kinase kinase kinase 7
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Synonyms:
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CSCF; FMD2; TAK1; MEKK7; TGF1a
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Swissprot:
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O43318
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Gene Accession:
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BC017715
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Purity:
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>85%, as determined by Coomassie blue stained SDS-PAGE
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Expression system:
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Escherichia coli
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Tags:
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His tag C-Terminus, GST tag N-Terminus
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Background:
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The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
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