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  • 產品名稱：NFKB1抗原（重組蛋白）

  • 產品型號：1mg
  • 產品廠商：通蔚生物
  • 產品價格：3580
  • 產品庫存：35
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詳情介紹：


中文名稱： NFKB1抗原（重組蛋白）

英文名稱： NFKB1 Antigen (Recombinant Protein)

儲     存：  冷凍（-20℃）

相關類別： 抗原

概     述

Fusion protein corresponding to a region derived from 619-968 amino acids of human NFKB1

技術規(guī)格

Full name:

nuclear factor kappa B subunit 1

Synonyms:

p50; KBF1; p105; EBP-1; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1

Swissprot:

P19838

Gene Accession:

BC051765

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.






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