英文名稱: Anti-H2AFX (Phospho-Ser139) rabbit polyclonal antibody
別 名: H2AX; H2A.X; H2A/X
相關(guān)類別: 一抗
儲(chǔ) 存: 冷凍(-20℃) 避光
宿 主: Rabbit
抗 原: H2AFX (Phospho-Ser139)
反應(yīng)種屬: Human
標(biāo) 記 物: Unconjugate
克隆類型: rabbit polyclonal
技術(shù)規(guī)格
Background: |
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. |
Applications: |
WB, IF |
Name of antibody: |
H2AFX (Phospho-Ser139) |
Immunogen: |
Synthetic peptide of human H2AFX (Phospho-Ser139) |
Full name: |
H2A histone family, member X (Phospho-Ser139) |
Synonyms: |
H2AX; H2A.X; H2A/X |
SwissProt: |
P16104 |
WB Predicted band size: |
15 kDa |
WB Positive control: |
HT29 cells treated with UV |
WB Recommended dilution: |
500-1000 |
IF Positive control: |
Hela cells |
IF Recommended dilution |
100-200 |