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  • 產(chǎn)品名稱：CDKN2A 抗原

  • 產(chǎn)品型號：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價(jià)格：350
  • 產(chǎn)品庫存：35
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CDKN2A 抗原（重組蛋白）深獲顧客信賴外，更帶給顧客喜悅和滿足，公司員工亦因此找到工作及生活的意義，將緊跟經(jīng)營管理和科學(xué)技術(shù)發(fā)展的步伐，提升和加強(qiáng)公司的市場競爭力，同心協(xié)力，盡展創(chuàng)意，致力于可持續(xù)發(fā)展、向社會(huì)盡責(zé)的企業(yè)宗旨。
詳情介紹：
中文名稱： CDKN2A 抗原 

英文名稱： CDKN2A Antigen

相關(guān)類別： 抗原

儲(chǔ)     存：  冷凍（-20℃） 

概     述

Synthetic peptide corresponding to a region derived from 144-156 amino acids of human cyclin-dependent kinase inhibitor 2A

技術(shù)規(guī)格

Background

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.

Gene Accession

NP_000068

Swissprot

P42771

Synonyms

ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A

Full name

cyclin-dependent kinase inhibitor 2A







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