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  • 產(chǎn)品名稱:RNF111 抗原(重組蛋白)

  • 產(chǎn)品型號(hào):100ug
  • 產(chǎn)品廠商:通蔚生物
  • 產(chǎn)品價(jià)格:800
  • 產(chǎn)品庫(kù)存:35
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詳情介紹:

中文名稱: RNF111 抗原(重組蛋白)

英文名稱: RNF111 Antigen (Recombinant Protein)

別     名:  ring finger protein 111; ARK; hRNF111

儲(chǔ)     存:  冷凍(-20℃)

相關(guān)類別: 抗原

概     述

Fusion protein corresponding to a region derived from 850-986 amino acids of human RNF111

技術(shù)規(guī)格

Full name:

ring finger protein 111

Synonyms:

ARK; hRNF111

Swissprot:

Q6ZNA4

Gene Accession:

BC010369

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.





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