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  • 產(chǎn)品名稱：兔抗MAP3K5(Ab966)多克隆抗體

  • 產(chǎn)品型號：100ul
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：1560
  • 產(chǎn)品庫存：60
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兔抗MAP3K5(Ab-966)多克隆抗體將進一步加強人才培養(yǎng)、產(chǎn)品創(chuàng)xin，持續(xù)不斷地提升企業(yè)核心竟爭力，實現(xiàn)具有高科技產(chǎn)業(yè)體系、知識化創(chuàng)業(yè)團隊的國際化企業(yè)，更好、更快捷、更全方位的服務(wù)于生命科學領(lǐng)域，迎接新一輪世界經(jīng)濟一體化所帶來的機遇與挑戰(zhàn)。
詳情介紹：


中文名稱：  兔抗MAP3K5(Ab-966)多克隆抗體     

英文名稱： Anti-MAP3K5(Ab-966) rabbit polyclonal antibody

別      名： ASK1; MEKK5; MAPKKK5

相關(guān)類別： 一抗

儲      存： 冷凍（-20℃）

抗      原： MAP3K5(Ab-966)

宿      主： Rabbit

反應(yīng)種屬： Human, Mouse, Rat

標 記 物： Unconjugate

克隆類型： rabbit polyclonal

技術(shù)規(guī)格

IF Recommended dilution

100-200

IF Positive control:

Hela cells

WB Recommended dilution:

500-1000

WB Positive control:

293 and Hela cell lysates

WB Predicted band size:

155 kDa

IHC Recommend dilution:

50-100

IHC positive control:

Human breast carcinoma

SwissProt:

Q99683

Synonyms:

ASK1; MEKK5; MAPKKK5

Full name:

mitogen-activated protein kinase kinase kinase 5

Immunogen:

Peptide sequence around aa.964-968 (S-I-S-L-P) derived from Human MAP3K5

Name of antibody:

MAP3K5(Ab-966)

Applications:

WB, IHC, IF

Background:

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.





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